This handbook presents a comprehensive and scientifically grounded examination of the toxicology of natural substances, focusing on their occurrence, behaviour, and impact within biological and environmental systems. It explores the complex interactions between naturally occurring toxins and living organisms, emphasising their presence in food, microorganisms, plants, and animal-derived substances. The handbook develops a clear understanding of how toxic agents are produced, transmitted, and manifested, integrating microbiological, biochemical, and environmental perspectives. It further considers the implications for public health, food safety, and ecological balance, highlighting the need for careful assessment and management of natural toxic hazards. Emphasis is placed on analytical approaches, detection methods, and preventive strategies that support safe handling and consumption. The discussion reflects contemporary developments in toxicological science, encouraging a critical and informed approach to understanding natural toxicity in diverse contexts.

This handbook is intended for researchers, health professionals, and advanced students seeking to deepen their understanding of toxicological processes. It supports the development of analytical skills, scientific awareness, and practical insight required for effective risk assessment and management of natural toxic substances.